It is important to remember that insulin secretion is the result of changes in the ß-cell's membrane potential and calcium-dependent action potentials. All cellular modifications can influence these processes and, therefore, the beta cell's rate of insulin secretion. The system is quite sensitive to a wide variety of physiological factors.
The Henderson-Hasselbalch equation provides a general solution to the quantitative treatment of acid-base equilibrium in biological system. This article explains how to derive Henderson-Hasselbalch Equation. http://www.biochemden.in/2013/10/henderson-hasselbalch-equation.html