Tuberous Sclerosis Case from German physician Richard Kothe, 1903 Tuberous sclerosis is not to be confused with tuberculosis. It’s an autosomal dominant, multi-system disorder, but almost 2/3 of cases are sporadic mutations. The periungual fibromas illustrated here are one of the key diagnostic criteria for the Tuberous Sclerosis Complex. Illustration from Wikimedia Commons
A genetic disease characterized by multiple neurofibromas and pigmented spots on the skin, sometimes accompanied by bone deformity and a predisposition to cancers, especially of the brain. Also calledmultiple neurofibroma, neuromatosis, Recklinghausen’s disease, von Recklinghausen’s disease.
IMPETIGO, 1865 This photograph published in 1865 by British dermatologist Alexander Balmanno Squire in his text Photographs (Colored from Life) of the Diseases of the Skin demonstrates the British style of fully over-painting photographs to best show disease conditions. Impetigo a superficial skin infection caused by Staphylococcus aureus and Streptococcus pyoegnes. I
Hydrocephaly of the infant. Hydrocephalic babies rarely live past 3-4 years old (if they’re lucky) without a shunt installed in their cranial cavity; these shunts did not become commonplace until the 20th cent
Lupus Erythematosus The autoimmune disease known as lupus is most commonly found in women of childbearing age (15-35), but has the potential to affect anyone. It’s also known as “the great imitator”, as the symptoms that people experience can mimic many other diseases and conditions. Seen here is the most common form of lupus, systemic lupus erythematosus , it produces a " butterfly" rash over cheeks and nose. From Diseases of the Skin, 1923.
Pellagra. " Fig. 1, 3 and 4. Skin lesion when pellagra. Fig. 2. Changes in the mucous membrane of the tongue when pellagra." Pellagra is a disease caused by a deficiency in the body of nicotinic acid and other B vitamines, characterized by lesions of the skin, digestive tract etc