The Old Fashioned cocktail is made by muddling sugar with bitters, then Bourbon or rye whiskey. The drink is usually finished with a twist of citrus rind and a cocktail cherry. It is traditionally served in an Old Fashioned glass, which is named after this very drink.
The Manhattan cocktail is made by stirring together rye or Canadian whiskey with sweet red vermouth and a dash of bitters. The drink is usually finished with a cocktail cherry and is traditionally served in a cocktail glass.