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Retroviruses like HIV depress selenium levels in their hosts by encoding the gene for the human selonenzyme glutathione peroxidase. This allows the virus to replicate indefinitely by continuously depriving the host of glutathione (an inhibitor of reverse transcriptase,) and the four basic components of glutathione peroxidase: selenium, cysteine, glutamine and tryptophan. As levels of selenium decline so do CD4 cells which allow "opportunistic" pathogens to invade the immune system and…

Human telomerase is a ribonucleoprotein complex, constituted by a catalytic subunit (hTERT), responsible to regulate the enzymatic activity as a reverse transcriptase.@

from Healthinnovations

Scientists identify new and beneficial function of endogenous retroviruses in immune response.

Hypothetical model of signaling events in the TI-2 antibody response. Upon BCR engagement by TI-2 antigen, signaling from the BCR via Btk and NF-κB leads to transcriptional activation of numerous ERV genes. Resulting transcripts are translated to produce reverse transcriptase(s) (RT), endogenous MLV Env, and possibly other ERV proteins. The activity of RT enzymes results in retrotranscription of ERV mRNAs and consequent elevation of ERV cDNA in the cytoplasm of the same cell. These ERV ...


Atripla is a combination therapy that targets reverse transcriptase and stops HIV DNA synthesis.


Human Immunodeficiency Virus Reverse Transcriptase: A Bench-to-bedside Success (Hardcover)

Human Immunodeficiency Virus Reverse Transcriptase: A Bench-to-bedside Success