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The refractory period is when it is difficult to restimulate a region of a neuron during an action potential and for a little time after. It is divided into two phases: the absolute refractory period lasts from the start of the action potential until the cell returns to RMP, in which no stimulus can trigger a new action potential; the relative refractory period lasts until the end of hyperpolarization, in which a new action potential can be triggered only with an unusually strong stimulus.

How does Sotalol work

Sotalol works to control the rhythm of the heart by increasing the refractory period and blocking beta receptors in the heart. This means it can decrease th

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Methylation of the E. coli replication origin creates a refractory period for DNA initiation