Tamoxifen induces remyelination Gonzalez GA Hofer MP Syed YA Amaral AI Rundle J Rahman S Zhao C Kotter MR. Tamoxifen accelerates the repair of demyelinated lesions in the central nervous system. Sci Rep. 2016;6:31599. Enhancing central nervous system (CNS) myelin regeneration is recognized as an important strategy to ameliorate the devastating consequences of demyelinating diseases such as multiple sclerosis. Previous findings have indicated that myelin proteins which accumulate following…
Researchers identify cellular regulator of glucose transport in the human body.
Researchers from UT Southwestern have gleaned a key cellular mechanism of how the body adjusts glucose levels, an important process that when abnormal can promote diabetes, cancer, and rare genetic diseases. The researchers determined that an enzyme called Protein Kinase C (PKC) can regulate whether more or less glucose should be transported into cells, serving as a kind of thermostat to ensure that proper levels are maintained.
Yersinia pestis, the causative organism of Plague, is widely recognized as a potential bioterrorism threat. Due to the absence of homologs in human, Shikimate Kinase (SK) is considered as an excellent drug target in several bacterial and protozoan parasites. Ample literature evidences confirm the suitability of this protein as a good target @ http://www.omicsonline.com/open-access/shikimate-kinase-of-yersinia-pestis-a-sequence-structural-and-functionalanalysis-2090-4924-1000119.php?aid=71775