P glycoprotein

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Piperine is an alkaloid extracted from black pepper (P. nigrum) and long pepper (P. longum). Previous studies have shown that piperine has anti-inflammatory, antiarthritic and anti-depressant effects [8] [9]. Piperine has also been known to inhibit CYP3A4 and P-glycoprotein due to which it has been used to enhance the bioavailability of other drugs [10]. When co-administered with curcumin, piperine increased the bioavailability of curcumin by 2000% [11]. In a clinical study, simultaneous…

Strategy Developed to Improve Delivery of Medicines to the Brain - The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

Antibodies and their antigen. Computer model showing the molecular structure of two anti-P-glycoprotein antibodies (upper left and right) and the P-glycoprotein (blue) to which they respond. These antibodies will bind to the glycoprotein, preventing it from functioning. ©Laguna Design/Science Source

Figure 3: Unhealthy diets such as high fat diets downregulate hepatic drug metabolism with the corruption of insulin therapy in diabetes and aging. Amyloid beta metabolism in the brain and liver are connected to drug metabolism and defective hepatic drug metabolism may be the primary defect in Type 3 diabetes with acceleration of neuronal apoptosis by abnormal brain amyloid beta metabolism associated with Type 1 or Type 2 diabetes. Abbreviations: P-gp1, P glycoprotein, PXR, pregnane X…

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Thou shall have a fishy on a little dishy thou shall have a fishy when the 3Rs boats come in Kulkarni P Yellanki S Medishetti R Sriram D Saxena U Yogeeswari P. Novel Zebrafish EAE model: A quick in vivo screen for multiple sclerosis. Mult Scler Relat Disord. 2017 Jan;11:32-39. doi: 10.1016/j.msard.2016.11.010. INTRODUCTION: METHODS: RESULTS: DISCUSSION: Highlights Zebrafish develop EAE Zebrafish EAE is treated with MS DMT You don't need to use mice or larger animals to look for…

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HCG Drops is a glycoprotein hormone produced in pregnancy that is made by developing embryo soon after conception and later by the syncytiotrophoblast

The blood–brain barrier allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function. On the other hand, the blood–brain barrier may prevent the entry of lipophilic, potential neurotoxins by way of an active transport mechanism mediated by P-glycoprotein.

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