Osteogenesis Imperfecta Foundation. Also known as “Brittle Bone Disease,” OI is characterized by varying degrees of collagen production impairment. Milder forms of this condition often goes undiagnosed and is mistaken for child abuse as the primary manifestation is multiple fractures, often seen in various phases of healing.
July 29, 2013: Osteogenesis imperfecta (OI and sometimes known as brittle bone disease, is a congenital bone disorder. People with OI are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of Type-I collagen. This deficiency arises from an amino acid substitution of glycine to bulkier amino acids in the collagen triple helix structure. If the body does not destroy improper collagen, brittle bones are formed.