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Bradley Wiggins downplays his achievements as he praises talented team mates after Rio gold

Rio 2016: Bradley Wiggins downplays his achievements as he praises talented team mates after Rio gold

Salvia divinorum leaves contain over a dozen unique chemicals, including Salvinorin-A - the most potent naturally occurring psychedelic substance known. It is about 10 times more potent than psilocybin, for instance. Salvinorin-A is a selective kappa opioid receptor agonist, which is unlike any other psychoactive substance. Drugs like psilocybin, LSD, and MDMA produce their psychedelic effects by activating part of the serotonin system. Salvia does not affect t...


Vivitrol is an opiate antagonist that works by attaching to the brain’s opioid receptors and blocks the euphoric feelings associated with intoxication. Luckily, the drug does not block the brain from experiencing pleasure derived from other enjoyable activities. Vivitrol for opiate addiction drastically reduces cravings.

Back off, stranger, that's my mate! The role of kappa opioid receptors

PSM21 docked in opioid receptor

μ receptor | Opioid receptors | IUPHAR/BPS Guide to PHARMACOLOGY

Methods in Molecular Biology Vol.1230 Opioid Receptors Methods and Protocols | Sách Việt Nam

Taking Advantage of the Peripheral Opioid Receptor

Opioids work by attaching to opioid receptors in the brain, dulling pain, stimulating the reward system in the brain, and increasing the production of the neurotransmitter dopamine which gives the user a euphoric feeling.


The μOR bind enkephalins & beta-endorphin but has low affinity for dynorphins.The μOR exist presynaptically in the periaqueductal gray region, & in the superficial dorsal horn of the spinal cord (substantia gelatinosa of Rolando). μOR are also found in the intestinal tract & cause constipation. Activation of the μ receptor by morphine causes analgesia, sedation, slightly reduced blood pressure, itching, nausea, euphoria, decreased respiration, & miosis. Overdoses can cause circulatory…