There is evidence that NMDA receptor antagonists can cause a certain type of neurotoxicity or brain damage referred to as Olney's Lesions in rodents, although such damage has never been conclusively observed in primates like humans. However, adolescent cynomolgus monkeys that were injected daily for six months with the non-competitive NMDA antagonist ketamine showed decreased locomotor activity and increased apoptosis of cells in their prefrontal cortices.

There is evidence that NMDA receptor antagonists can cause a certain type of neurotoxicity or brain damage referred to as Olney's Lesions in rodents, although such damage has never been conclusively observed in primates like humans. However, adolescent cynomolgus monkeys that were injected daily for six months with the non-competitive NMDA antagonist ketamine showed decreased locomotor activity and increased apoptosis of cells in their prefrontal cortices.

Stopping anti-clotting medications in some patients with irregular heartbeats may raise the risk of stroke or blood clotting within a month, finds a new research.

Stopping anti-clotting medications in some patients with irregular heartbeats may raise the risk of stroke or blood clotting within a month, finds a new research.

NMDA receptor antagonist ... Can be used to treat resistant forms of Catatonia

NMDA receptor antagonist ... Can be used to treat resistant forms of Catatonia

Biochemistry of Memantine:   The drug belongs to a class of drugs called NMDA receptor antagonists, which reduce certain types of brain activity by binding to NMDA receptors on brain cells and blocking the activity of the neurotransmitter glutamate. At normal levels, glutamate aids in memory and learning, but if levels are too high, glutamate appears to overstimulate nerve cells, killing them through excitotoxicity.

Biochemistry of Memantine: The drug belongs to a class of drugs called NMDA receptor antagonists, which reduce certain types of brain activity by binding to NMDA receptors on brain cells and blocking the activity of the neurotransmitter glutamate. At normal levels, glutamate aids in memory and learning, but if levels are too high, glutamate appears to overstimulate nerve cells, killing them through excitotoxicity.

Ketamine Is….. an NMDA receptor antagonist that is usually used in anesthesia in humans and animals.  Often  delivered as an infusion or intramuscularly, or as a cream or gel (often in combination with other analgesics), Ketamine is effective, at least in the short term, in treating several chronic pain states …

Ketamine Is….. an NMDA receptor antagonist that is usually used in anesthesia in humans and animals. Often delivered as an infusion or intramuscularly, or as a cream or gel (often in combination with other analgesics), Ketamine is effective, at least in the short term, in treating several chronic pain states …

Alomone Labs D-AP5, a competitive NMDA receptor antagonist.

Alomone Labs D-AP5, a competitive NMDA receptor antagonist.

Halothane (brandname Fluothane).  Alkyl halide. General anesthetic. Inhaled. Start/maintain anaesthesia. Doesn't increase saliva, best when difficult to intubate. Not recommended for C-section. Replaced by sevoflurane & n/a commercially in US.  Activates GABA(A) and glycine receptors. NMDA receptor antagonist, inhibits nACh and voltage-gated sodium channels, and activates 5-HT3 and twin-pore K+ channels.

Halothane (brandname Fluothane). Alkyl halide. General anesthetic. Inhaled. Start/maintain anaesthesia. Doesn't increase saliva, best when difficult to intubate. Not recommended for C-section. Replaced by sevoflurane & n/a commercially in US. Activates GABA(A) and glycine receptors. NMDA receptor antagonist, inhibits nACh and voltage-gated sodium channels, and activates 5-HT3 and twin-pore K+ channels.

Methoxetamine (MXE) or 3-MeO-2-Oxo-PCE is a chemical of the arylcyclohexylamine class which has been sold as a designer drug.[1] It is a derivative of ketamine that also contains structural features of eticyclidine and 3-MeO-PCP. Methoxetamine is thought to behave as a NMDA receptor antagonist and dopamine reuptake inhibitor, though it has not been formally profiled pharmacologically.

Methoxetamine (MXE) or 3-MeO-2-Oxo-PCE is a chemical of the arylcyclohexylamine class which has been sold as a designer drug.[1] It is a derivative of ketamine that also contains structural features of eticyclidine and 3-MeO-PCP. Methoxetamine is thought to behave as a NMDA receptor antagonist and dopamine reuptake inhibitor, though it has not been formally profiled pharmacologically.

Phencyclidine (a complex clip of the chemical name 1-(1-phenylcyclohexyl)piperidine), (PCP) and known colloquially as angel dust or wet, is a recreational dissociative drug. Formerly used as an anesthetic agent, PCP exhibits both hallucinogenic and neurotoxic effects. PCP is an NMDA receptor antagonist.PCP is an NMDA receptor antagonist. PCP, like ketamine, also acts as a D2 receptor partial agonist. D2 receptor antagonists (such as haloperidol) can be used in the treatment of PCP psychosis.

Phencyclidine (a complex clip of the chemical name 1-(1-phenylcyclohexyl)piperidine), (PCP) and known colloquially as angel dust or wet, is a recreational dissociative drug. Formerly used as an anesthetic agent, PCP exhibits both hallucinogenic and neurotoxic effects. PCP is an NMDA receptor antagonist.PCP is an NMDA receptor antagonist. PCP, like ketamine, also acts as a D2 receptor partial agonist. D2 receptor antagonists (such as haloperidol) can be used in the treatment of PCP psychosis.

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