Types of microcytic, hypochromic anemia... Iron deficiency will have a high RDW with low ferritin... Thalassemia's will have normal RDW and elevated ferritin (due to RBC turnover)... after thalassemia is suspected, electrophoresis should be done to distinguish alpha (normal) from beta (elevated HbA2 levels)
Sideroblastic anemia. Presence of anemia + ringed sideroblasts. Hypochromic, BIMODAL RBC population. +/- Pappenheimer bodies (iron). Increased iron stores in BM. All iron studies are elevated (but distinguish from hemochromocytosis because SA has low hgb and low MCV). CAUSES: ACQUIRED = RARS, meds, alcohol, Pearson syndrome and low copper. VAST MAJORITY HAVE CLONAL DEFECT. MACROCYTIC. >15% RS. INHERITED = rare, X-linked. ALAS2 gene. MICROCYTIC. Can try giving a ton of B6.
Target cells. Red cells with thin membrane, peripheral rim of hemo- globin (Hb), and dark, central, Hb-containing area. They are frequently seen in Hb C disease, in hypochromic anemia, and in liver disease