Single axial CT of the head without contrast shows a well defined, calcified mass within the left frontal sinus. This is the typical appearance for a Sinonasal Osteoma. Classically they are asymptomatic, and thus are incidental findings on imaging studies done for other reasons. Sinonasal osteomas are the most common benign tumor of the sinuses. They can be associated with Gardner syndrome, an autosomal dominant transmitted familial adenomatous polyposis syndrome.
mesenteric fibromatosis in pt with Gardner syndrome (FAP) is more likely to recur. Gardner’s syndrome is an autosomal dominant familial disease with a female predilection and consists of numerous colorectal adenomatous polyps, osteomas, cutaneous cysts, soft tissue masses, and other manifestations. Gardner’s syndrome is related to familial adenomatous polyposis, a disorder caused by germline adenomatous polyposis coli (APC) gene mutations. It is associated with an 8-12% incidence of…
Lipomas: "A genetic disorder called familial multiple lipomatosis is known to cause lipoma nodules to develop. Cowden syndrome, adiposis dolorosa, Gardner’s syndrome and Madelung disease are also known to trigger the formation of lipomas." & more data on nodules generally
Gardner syndrome is a variant of Familial Adenomatous Polyposis (FAP) characterized by multiple, bilateral atypical CHRPE. TRIAD=intestinal polyps+skeletal hamartomas+soft tissue tumours (cysts, neurofibromas, etc). Over 50% will have dental anomalies. This condition can be seen as early as childhood and patients will develop colon cancer if left untreated.