Albrecht Altdorfer; "Battle at Issus" The Battle of Issus was the second great battle of Alexander's conquest of Asia. It occurred in southern Anatolia, in November 333 BC between the Hellenic League and Achaemenid Persia, ruled by Darius III. The Greek phalanx and their expertise at close combat drove the Persians from the field.
Alexander the Great at the Battle of Issus (stone). Alexander III of Macedon (356-323 BC); The Battle of Issus occured in southern Anatolia, in November 333 BC; the invading troops, under Alexander the Great, defeated the army personally led by Darius III of Achaemenid Persia