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BRAF: From Gene to Cancer Therapy

Get your students searching for #cancer #mutations in #genetic #datasets. This #classroom activity demonstrates the journey from cancer #gene to targetted medicine. Worksheets to download via @yourgenome


BRAF: From Gene to Cancer Therapy. A science, biology video resource

Obituary to Yvonne Brill, Rocket Scientist, dead at 88. (The obit was amended to take out the lead to the story that she made 'beef stroganoff' - FFS). Find the obit in the NY Times March 30 2013 written by Douglas Martin - Direct pin to the article wasn't permitted.

The BRAF gene is located on the long (q) arm of chromosome 7 at position 34.

A BRAF gene mutation in melanoma patients has been found to respond to MEK inhibitor drugs, providing a reason for routine screening and therapy in melanoma patients with the BRAF L597 mutation.


The American Academy of Dermatology has released a set of guidelines for people to reference in case a skin irritation could indicate something serious going on inside the body.

BRAF Gene Mutations Are Rare Events in Gastroenteropancreatic Neuroendocrine Tumors - Click on Image

from Medpage Today

Targeted Tx Slows Melanoma Progress

A new drug that targets mutated BRAF in metastatic #melanoma showed greater progression-free survival (PFS) compared with conventional chemotherapy, an open-label phase III trial found.


Drug-Resistant Melanoma Treatment May Be Enhanced: Study - More than 8,000 Americans are killed each year by melanoma — the deadliest form of skin cancer. The presence of mutations in a gene known as the BRAF gene drives approximately 40 percent of advanced melanoma tumors. | RedOrbit/Nov 2013

Colorectal carcinoma is the most frequent type of bowel cancer and the second most common tumour disease among men and women in Germany. So-called microsatellite stable colorectal cancer with mutations in the BRAF gene represents a particularly aggressive form. The BRAF gene produces the enzyme B-Raf, ...